Cannabis for chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME)

Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a condition that can cause:

• Extreme tiredness (fatigue)
• Pain
• Cognitive issues (‘brain fog’)
• Sleep disturbances

If you have CFS/ME, everyday tasks can be extremely difficult.

Why some people develop CFS/ME is unclear, and there is no known cure. It’s common for people who have fibromyalgia to also have CFS/ME.

Many people with CFS/ME struggle to find effective treatments, leading some to explore medical cannabis as a potential option. Cannabis has been used for centuries to manage pain, sleeping troubles, and inflammation, all of which are common CFS/ME symptoms.

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Research on cannabis for chronic fatigue syndrome

Research on cannabis for CFS/ME is limited, but some studies suggest it may help with symptoms like:

• Anxiety
• Chronic pain, particularly muscle or joint pain, nerve pain (neuropathy), and fibromyalgia
• Headaches and migraine
• Muscle twitches or spasms

Cannabinoids like cannabidiol (CBD) and tetrahydrocannabinol (THC) — the main active compounds in cannabis — interact with the body’s endocannabinoid system (ECS), which helps balance pain, sleep, and immune function.

CFS/ME is commonly associated with post-viral syndrome, such as long- or post-COVID. Cannabis may help manage symptoms associated with post-viral syndrome, like stress, fatigue, and inflammation.

CBD and beta-caryophyllene, a terpene in cannabis, might be particularly helpful because of their anti-inflammatory, anti-anxiety, and pain-relieving effects. Cannabigerol (CBG), another cannabinoid, has also been shown to reduce stress and anxiety.

Some research shows that cannabis may help with CFS/ME symptoms. But larger studies are needed to confirm these effects, and to better understand what role cannabis can play in treating CFS/ME.

Using cannabis for chronic fatigue syndrome

Cannabis may help relieve some of your CFS/ME symptoms, but it’s important to weigh the potential benefits and risks. While some people report improvement after using cannabis, it may not work for everyone.

Benefits

Cannabis has several potential benefits for CFS/ME and its related symptoms, including:

• Pain relief: Cannabis may help reduce chronic pain, especially nerve pain and headaches.
• Improved sleep: Certain cannabinoids, like THC and cannabinol (CBN), may help improve sleep.
• Lower inflammation: Some studies suggest that cannabinoids have anti-inflammatory properties.
• Mood support: Cannabis may help manage anxiety and depression, which are common in people with CFS/ME.

Risks and side effects

As with any medication, cannabis has potential risks and side effects.

• Cognitive effects: THC can cause memory and concentration issues, which may worsen brain fog.
• Fatigue: Some strains may cause you to feel more tired, exacerbating existing fatigue. One study shows that although many people find relief from fatigue after using cannabis, a number of people may experience worsened symptoms.
• Dependence risk: Frequent THC use can lead to dependency.

Is it legal?

Cannabis laws vary by state. In states where medical cannabis is legal, CFS/ME is not listed as a qualifying condition. However, a related symptom like chronic pain or anxiety may qualify you for medical cannabis.

More about chronic fatigue syndrome

CFS/ME can result from viral infections, a poorly functioning immune system, or severe physical or emotional stress.

Your doctor will diagnose you with CFS/ME by asking about your symptoms and ruling out other conditions.

Other treatments for chronic fatigue syndrome

There is no cure for CFS/ME. Your doctor will recommend a treatment plan to help you manage your symptoms.

Traditional therapies

Both drug and non-drug treatments are recommended to manage CFS/ME.

• Medications: Your doctor may prescribe pain relievers, sleep aids, and/or antidepressants.
• Physical therapy: Gentle movement can keep the muscles and joints healthy.
• Cognitive behavioral therapy (CBT): CBT may address underlying emotional stress.

Natural and alternative therapies

Natural and alternative therapies may help you with some CFS/ME symptoms.

• Pacing and energy management: Learning to pace yourself throughout the day may prevent overexertion and symptom flare-ups.
• Dietary changes: Making adjustments to your diet, such as reducing sugar, caffeine, and processed foods, may help alleviate symptoms.
• Herbal remedies: Some studies show that ginseng and echinacea may improve immune function in people with CFS/ME.
• Acupuncture: A study shows that acupuncture can help improve mood and relieve stress in people with CFS/ME.

Cannabis as part of your treatment plan for chronic fatigue syndrome

Cannabis may help you with some CFS/ME symptoms, but it should be part of a broader treatment plan. If you’re considering medical cannabis, consult with a healthcare professional to determine if it’s right for you.

Depending on your state’s laws, you may need a medical cannabis card to access cannabis legally. Leafwell’s telehealth services can help you get the process started.

Frequently asked questions

For more information about cannabis for CFS/ME, find answers to FAQs below.

Can weed help with chronic fatigue syndrome?

Cannabis may help with common symptoms like pain, poor sleep, and low mood, but more research is needed to confirm its effectiveness.

Can weed increase fatigue?

Yes, cannabis can increase fatigue. Effects can depend on strain, as strains with higher levels of myrcene and THC are associated with drowsiness.

What’s the best way to use cannabis for CFS/ME?

This depends on your unique symptoms.

• High-CBD products may help you during the day due to their lower risk of intoxication and drowsiness.
• High-THC products may help you sleep at night.

Which cannabinoids or terpenes are best for CFS/ME?

Cannabinoids and terpenes that may help with CFS/ME symptoms include:

• THC (low to moderate doses)
• THCV (low to moderate doses)
• CBD
• CBG
• Beta-caryophyllene
• Limonene
• Pinene
• Terpinolene

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